SIRT6 is one of seven known sirtuins—a family of proteins involved in regulating aging, DNA repair, metabolism, and inflammation.
Among them, SIRT6 is particularly notable for its role in maintaining genomic stability and promoting longevity. It functions as a histone deacetylase, helping to regulate gene expression, repair DNA damage, and control metabolic pathways related to glucose and fat metabolism.
Research has shown that increased SIRT6 activity is associated with longer lifespan in mammals, improved insulin sensitivity, and protection against age-related diseases such as cancer and neurodegeneration.
Because of its powerful anti-aging and healthspan-extending potential, SIRT6 is a growing focus in longevity science and nutritional research.
SIRT6 Friendly Food Guide
These foods contain nutrients and compounds that may support the activity of SIRT6, a key longevity gene involved in DNA repair, metabolism, and inflammation reduction.
| Food | Key Nutrients/Compounds | SIRT6 Role |
| Strawberries | Fisetin | Promotes SIRT6 expression, senolytic |
| Onions | Quercetin | May activate sirtuin pathways |
| Celery | Luteolin | Mild SIRT6 activation |
| Fatty Fish (Salmon, Mackerel) | Omega-3, NAD⁺ Precursors | Reduces inflammation, supports NAD⁺ |
| Mushrooms (Shiitake, Maitake) | Ergothioneine, NAD⁺ Precursors | Supports mitochondrial health |
| Broccoli Sprouts | Sulforaphane | Activates antioxidant defense systems |
| Natto | Spermidine | Supports autophagy and cellular renewal |
| Eggs | Choline, Tryptophan | NAD⁺ synthesis support |
| Green Tea | EGCG | Antioxidant, potential indirect activator |
| Sunflower Seeds | Tryptophan, Vitamin B6 | Supports NAD⁺ and methylation |
Sirtuin Activation Supplement Stack
This stack includes supplements shown to support sirtuin function, through NAD⁺ enhancement, polyphenol activation, and cellular stress resilience.
| Supplement | Suggested Dose | Target |
| NMN or NR | 250–500 mg/day | NAD⁺ supply for all sirtuins |
| Resveratrol | 100–250 mg/day | Activates SIRT1, supports metabolism |
| Fisetin | 1000–1500 mg (2 days/month) | Senolytic, may enhance SIRT6 expression |
| Spermidine | 1–3 mg/day | Autophagy, supports SIRT6 and cellular longevity |
| Luteolin | 50–100 mg/day | Mild SIRT6 activator, anti-inflammatory |
| Quercetin | 250–500 mg/day | Supports sirtuin activation and inflammation balance |
| PQQ | 10–20 mg/day | Mitochondrial biogenesis, antioxidant support |
| Vitamin B3 (Niacinamide or Nicotinic Acid) | 100–300 mg/day | Boosts NAD⁺ levels |
| Curcumin | 500–1000 mg/day | Epigenetic modulation, anti-inflammatory |
