Contents
What is Fisetin?
- A natural flavonoid found in various fruits and vegetables, particularly strawberries.
- Acts as a senolytic agent, helping to clear out damaged or “senescent” cells.
- Known for its anti-inflammatory, antioxidant, and potential longevity-supporting properties.
Main Benefits
| Health Area | Effects |
|---|---|
| Cellular Health | Removes senescent cells, promotes healthier aging |
| Cognitive Function | Supports memory, learning, and brain protection |
| Inflammation Reduction | Lowers markers of systemic inflammation |
| Antioxidant Defense | Neutralizes harmful free radicals |
| Heart Health | May protect vascular function and reduce oxidative stress |
Typical Dosage
- 100 to 500 mg/day for general antioxidant support.
- Up to 1,000 mg/day or higher in short-term senolytic protocols (for example, 2 days per month).
- Clinical senolytic studies often use high doses for short periods rather than daily low doses.
Best Time to Take
- Can be taken with meals, especially those containing healthy fats to enhance absorption.
- For senolytic purposes, may be taken in pulsed dosing (e.g., two consecutive days monthly).
Possible Side Effects
- Generally well tolerated at moderate doses.
- High doses may cause mild gastrointestinal discomfort in some individuals.
- Limited human clinical data at very high dosages; caution and medical supervision recommended for experimental use.
Sources of Fisetin
- Strawberries (highest natural source)
- Apples
- Persimmons
- Onions
- Cucumbers
However, dietary amounts are much lower than those used in supplementation.
Buying Tips
- Look for supplements that provide pure Fisetin with minimal fillers.
- Products that include a lipid delivery system (like liposomal Fisetin) may enhance bioavailability.
- Some formulas combine Fisetin with other senolytics like quercetin or piperine for enhanced effects.
